a Record control number WOS:000254456100004

a ISSN 0944-1174

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WI 140

b Item number .E34 2008

a Personal name Bulbul, Mehmet.

h Medium Electronic Document

a Title Effect of orexin-a on ischemia-reperfusion-induced gastric damage in rats

c Statement of responsibility, etc Mehmet Bulbul, Ruken Tan, Burcu Gemici, Gozde Ongut, V. Nimet Izgut-Uysal.

a Place of publication, distribution, etc Springer Tokyo,

c Date of publication, distribution, etc 2008.

b Name of publisher, distributor, etc Tokyo

a Summary, etc Background. Orexins are involved in the regulation of sleeping behavior and energy homeostasis, and they are also implicated in the regulation of gastrointestinal functions. Previous reports have demonstrated the expression of orexin receptors in the gastrointestinal system. The aim of this study was to investigate the gastroprotective effect of orexin-A in ischemia-reperfusion-induced gastric mucosal injury. Methods. The gastric ischemia-reperfusion model was established by clamping the celiac artery for 30 min and reperfusing for 60 min. Orexin-A was administered in doses of 500 pmol center dot kg(-1)center dot min(-1) by infusion throughout the ischemia-reperfusion period. The mean lesion area, gastric prostaglandin E(2) and mucus content, myeloperoxidase activity, and production of thiobarbituric acid reactive substances were measured. Results. Orexin-A significantly attenuated the ischemia-reperfusion-induced gastric lesions and also decreased myeloperoxidase activity and the thiobarbituric acid reactive substances content in gastric mucosa of rats exposed to ischemia-reperfusion. However, the decline in gastric prostaglandin E(2) and mucus content was not restored by orexin-A treatment. Conclusions. Orexin-A exhibited a gastroprotective effect against ischemia-reperfusion-induced lesions by decreasing neutrophil activation and lipid peroxidation.

a Topical term or geographic name as entry element Gastroenterology & Hepatology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Orexin-A

a Topical term or geographic name as entry element Ischemia-Reperfusion

a Topical term or geographic name as entry element Mucus

a Topical term or geographic name as entry element Ghrelin-Induced Gastroprotection

a Topical term or geographic name as entry element Mucosal Injury

g Relationship information MAR 2008, Vol 43 Issue 3, p202-207

x International Standard Serial Number 09441174

t Title Journal Of Gastroenterology

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s00535-007-2148-3